Recognised as a talented footballer from a young age, Spargo was a part of the Greater Western Sydney Academy from twelve years of age. He attended Melbourne Grammar School for the remaining three years of high school,

Charlie was drafted by Melbourne with their first selection and twenty-ninth overall in the 2017 national draft. He was eased into pre-season training with Melbourne due to a shoulder injury sustained in his draft year but has since gone on to play 27 AFL games across his first three seasons.